With the advent of nanotechnology the interaction of nanoparticles (NPs) with biological systems including living cells has become one of the most intriguing areas of basic and applied research at the interface to biology. As nanoparticles are of the same size scale as typical cellular components and proteins, such particles are suspected to evade the natural defences of the human organism and may lead to permanent cell damages. Although there is substantial evidence from recent toxicological studies that nanoparticles may cause adverse heath effects, the fundamental cause-effect relationships have not yet been investigated more